Boil the manicotti according to package directions until a little more than half done. Drain and lay the manicotti out across a cutting board in preparation to be stuffed with cheese filling.
While you are waiting for the water to boil and waiting for the manicotti to cook, spray a 9x13 baking dish with non-stick cooking spray and set aside. Preheat the oven to 350 degrees.
Mix together the cottage cheese, egg, parmesan cheese and colby jack cheese in a mixing bowl and set aside.
Whisk together the spaghetti sauce, italian seasoning, garlic powder, and onion powder. Set aside.
After the manicotti is half cooked and drained and laid out, allow it cool just long enough that you can handle it without burning your fingers. This doesn't take long. Hold the manicotti at an angle with the bottom resting against a cutting board and stuff the shell with the cottage cheese/cheese mixture.
Place each stuffed manicotti shell in the prepared baking dish.
Pour the spaghetti sauce mix over the stuffed shells.
Sprinkle the shredded mozzarella over the top.
Either bake at 350 degrees for 40 minutes, cover and put the fridge to bake later, or properly cover with foil to freeze for a later use.